Tesofensine
Also known as NS2330
An oral appetite suppressant that works on brain chemistry, not gut hormones.
How it's taken (route)
swallowed as a capsule or pill, usually on an empty stomach
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- Documented dose
- 250–500 mcg
- Typical frequency
- One capsule once daily, morning
- Cycle
- 12 weeks on, 8 off
- Half-life
- Very long — around 8 days
- Regulatory status
- Investigational — not approved.
No syringe needed
Tesofensine is taken oral capsule or tablet, so there is no U-100 syringe draw for it.
What it does
Tesofensine keeps more dopamine, noradrenaline and serotonin active in the brain, which strongly blunts appetite and lifts energy and motivation. People use it when GLP-1s cause too much nausea, or to break a plateau. It is a stimulant-type compound, so blood pressure matters.
Mechanism
A triple monoamine reuptake inhibitor — it blocks reuptake of dopamine, noradrenaline and serotonin, reducing hunger signalling in the hypothalamus.
Storage — lyophilisedwhat's this?
Store capsules cool and dry.
Storage — reconstitutedwhat's this?
Not applicable — oral capsules.
Reconstitution noteswhat's this?
No mixing needed. Typically 250-500 mcg once daily in the morning. The long half-life means levels build for one to two weeks — do not increase the dose early.
Stacks well with
- 5-Amino-1MQAppetite control plus a separate fat-metabolism pathway.
- BAM-15Both oral; one cuts intake, the other raises energy burn.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Insomnia
- Dry mouth
- Raised heart rate and blood pressure
- Irritability
- Constipation
Contraindications noted
- High blood pressure
- Heart disease
- MAO inhibitors or SSRIs
- Anxiety disorders
Research notes
Trials showed weight loss beyond most single-agent drugs, but blood pressure and heart rate increases stopped its approval path.
Track this properly
Work out syringe units with the calculator, or set up a full schedule in about a minute.
Reference information only, not medical advice. See our medical disclaimer.