Orforglipron
Also known as LY3502970
A once-daily GLP-1 pill — no injections and no food or water restrictions.
How it's taken (route)
swallowed as a capsule or pill, usually on an empty stomach
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- Documented dose
- 1500–36000 mcg
- Typical frequency
- Once daily at any time of day
- Cycle
- 26 weeks on, 26 off
- Half-life
- Suited to once-daily dosing
- Regulatory status
- Under regulatory review; not yet a general prescription product.
No syringe needed
Orforglipron is taken oral capsule or tablet, so there is no U-100 syringe draw for it.
What it does
Orforglipron does what semaglutide does to appetite, but as a small-molecule tablet. People use it for steady weight loss and blood-sugar control without needles, and unlike older oral GLP-1s it does not need to be taken fasted with a specific amount of water.
Mechanism
A non-peptide GLP-1 receptor agonist: it slows stomach emptying, increases satiety, and improves insulin response.
Storage — lyophilisedwhat's this?
Store tablets cool and dry.
Storage — reconstitutedwhat's this?
Not applicable — oral tablets.
Reconstitution noteswhat's this?
No mixing. Titrate slowly with a pill splitter: week 1 a quarter tablet (1.5 mg), week 2 a half (3 mg), weeks 3-6 one tablet (6 mg), then step up roughly every 4 weeks toward 36 mg as tolerated. Cycles run 18-36 weeks with a similar break.
Stacks well with
- 5-Amino-1MQMetabolic support alongside appetite suppression, both oral.
- TesamorelinAdds a visceral-fat target to general weight loss.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Nausea
- Constipation or diarrhoea
- Reduced appetite
- Fatigue
- Vomiting if titrated too fast
Contraindications noted
- Personal or family history of medullary thyroid cancer
- MEN2
- Pancreatitis
- Pregnancy
Research notes
Large phase 3 trials reported weight loss in the same range as injectable GLP-1s. Titrate slowly — most side effects come from moving up too quickly.
Track this properly
Work out syringe units with the calculator, or set up a full schedule in about a minute.
Reference information only, not medical advice. See our medical disclaimer.