FOX04-DRI
Also known as FOXO4-DRI, Proxofim
A senolytic peptide used to clear worn-out "zombie" cells.
How it's taken (route)
a small shot into the fat just under the skin (belly, thigh, or love handle)
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- Documented dose
- 250–500 mcg
- Typical frequency
- Once daily
- Cycle
- 12 weeks on, 6 off
- Half-life
- Short
- Common vial sizes
- 10 mg
- Regulatory status
- Research chemical — not approved for human use.
Dose on a U-100 syringe (250–500 mcg)
| Vial | BAC water | Draw |
|---|---|---|
| 10 mg | 2.5 mL | 6.3–13 units |
| 10 mg | 3 mL | 7.5–15 units |
On a U-100 syringe, 100 units = 1 mL, and the syringe holds 100 units total. Most people keep a single subcutaneous injection under about 50 units — bigger volumes are usually mixed stronger (less water) or split into two shots. Only mixes that fit in one syringe are shown. Always double-check with the reconstitution calculator.
What it does
FOX04-DRI is run in longevity protocols to help the body clear senescent cells — cells that have stopped dividing but keep pumping out inflammatory signals. People report better recovery, skin quality, and general vitality over a cycle, though the evidence is preclinical.
Mechanism
Disrupts the FOXO4-p53 interaction inside senescent cells, releasing p53 and allowing those cells to undergo apoptosis.
Storage — lyophilisedwhat's this?
Refrigerate the sealed vial.
Storage — reconstitutedwhat's this?
Refrigerate and use within about 4 weeks.
Reconstitution noteswhat's this?
Mix a 10 mg vial with 3 mL of bacteriostatic water (about 3.3 mg/mL). Weeks 1-4: 8 units (250 mcg). Weeks 5-8: 11 units (375 mcg). Weeks 9-16: 15 units (500 mcg).
Stacks well with
- EpitalonClearing senescent cells alongside telomere-focused longevity work.
- NAD+Cellular clean-up plus cellular energy.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Fatigue during the first days
- Injection site reactions
- Temporary aches as cells clear
Contraindications noted
- Pregnancy
- Active infection or recent surgery
Research notes
Famous for mouse studies showing restored fur and kidney function. No human trials exist.
Track this properly
Work out syringe units with the calculator, or set up a full schedule in about a minute.
Reference information only, not medical advice. See our medical disclaimer.