NAD+
Also known as Nicotinamide adenine dinucleotide
Coenzyme used in energy metabolism and longevity protocols.
- Category
- longevity
- Route
- subq
- Documented dose
- 50000–100000 mcg
- Typical frequency
- 2-3 times weekly
- Cycle
- 4 weeks on, 2 off
- Half-life
- Minutes (rapid clearance)
- Common vial sizes
- 100 mg, 500 mg
- Regulatory status
- Sold as a supplement; injectable use unapproved.
What it does
Not a peptide but a coenzyme every cell uses to turn food into usable energy and to run DNA repair. Levels fall steadily with age, which is why it turns up in longevity protocols. What people look into it for: • More physical and mental energy, and less brain fog • Mitochondrial health and cellular repair • Recovery from heavy training, illness or jet lag • Healthy-ageing and cognitive support Injections and IV drips are used because oral NAD+ is poorly absorbed. Fast administration commonly causes a wave of flushing, nausea or chest tightness, so it is given slowly.
Mechanism
Substrate for sirtuins and PARPs; central to redox metabolism.
Storage — lyophilised
Refrigerate 2-8C, protect from light.
Storage — reconstituted
Refrigerate 2-8C, use within ~28 days.
Reconstitution notes
Large volumes; inject slowly to reduce discomfort.
Commonly stacked with
- MOTS-c
- 5-Amino-1MQ
Commonly reported side effects
- Injection-site pain
- Flushing
- Nausea
- Chest tightness if injected fast
Contraindications noted
- Pregnancy or breastfeeding
Research notes
Subcutaneous dosing is uncomfortable; IV infusions are the studied route.
Track this properly
Work out syringe units with the free calculator, or set up a full schedule in about a minute.
Reference information only, not medical advice. See our medical disclaimer.