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cognitivelongevity

Dihexa

Also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408

An oral peptide studied for building new brain connections.

How it's taken (route)

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Documented dose
5000–20000 mcg
Typical frequency
Once daily, or split into 2-3 doses
Cycle
10 weeks on, 5 off
Half-life
Long relative to most peptides
Regulatory status
Research chemical — not approved for human use.

No syringe needed

Dihexa is taken oral capsule or tablet, so there is no U-100 syringe draw for it.

What it does

Dihexa is used by people looking for a strong, long-lasting cognitive effect — better memory formation, faster learning, and clearer thinking. It is taken as a capsule, usually in the morning on an empty stomach, in 8-12 week blocks.

Mechanism

Boosts hepatocyte growth factor (HGF) signalling at the c-Met receptor, which drives the formation of new synapses.

Storage — lyophilisedwhat's this?

Store capsules cool and dry.

Storage — reconstitutedwhat's this?

Not applicable — oral capsules.

Reconstitution noteswhat's this?

No mixing needed. 1-4 capsules (5-20 mg) per day, taken on an empty stomach 30 minutes before food. Morning dosing avoids sleep disruption.

Stacks well with

Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.

Commonly reported side effects

  • Sleep disturbance if dosed late
  • Headache
  • Overstimulation

Contraindications noted

  • Any active cancer — synapse-growth signalling is not selective

Research notes

Animal work is striking, but there is no published human trial. The growth-factor mechanism is the main reason for caution.

Track this properly

Work out syringe units with the calculator, or set up a full schedule in about a minute.

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Reference information only, not medical advice. See our medical disclaimer.