Semax
Also known as ACTH 4-10 analogue
Russian nootropic peptide used intranasally.
- Category
- cognitive
- Route
- nasal
- Documented dose
- 250–1000 mcg
- Typical frequency
- Once or twice daily
- Cycle
- 4 weeks on, 2 off
- Half-life
- ~30 minutes
- Common vial sizes
- 5 mg, 10 mg
- Regulatory status
- Approved in Russia only; unapproved elsewhere.
What it does
A modified fragment of ACTH with the hormonal effects stripped out, developed in Russia as a nootropic and stroke treatment. It raises BDNF and supports dopamine and serotonin activity. What people look into it for: • Sharper focus, memory and mental stamina • Protecting brain cells during and after stress or injury • Lifting low mood and motivation • Faster mental recovery after intense cognitive work Usually taken as a nasal spray. Widely used in Russia, but little Western clinical data.
Mechanism
ACTH fragment analogue increasing BDNF and modulating dopaminergic and serotonergic tone.
Storage — lyophilised
Refrigerate 2-8C, protect from light.
Storage — reconstituted
Refrigerate 2-8C, use within ~28 days.
Reconstitution notes
Usually reconstituted for nasal drops rather than injection.
Commonly stacked with
- Selank
Commonly reported side effects
- Nasal irritation
- Headache
- Irritability
Contraindications noted
- Pregnancy or breastfeeding
Research notes
Approved in Russia; little Western clinical data.
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Reference information only, not medical advice. See our medical disclaimer.