VIP
Also known as Vasoactive Intestinal Peptide
A nasal peptide used in chronic inflammatory and mold-illness protocols.
How it's taken (route)
sprayed into the nose and absorbed through the nasal lining — no needles
New to peptides? Start with the beginner's guide.
- Documented dose
- 50–200 mcg
- Typical frequency
- One spray per nostril up to 4 times daily
- Cycle
- 12 weeks on, 4 off
- Half-life
- Very short in blood
- Regulatory status
- Compounded prescription in some countries; otherwise research use.
No syringe needed
VIP is taken nasal spray, so there is no U-100 syringe draw for it.
What it does
VIP is usually the last step in chronic inflammatory response protocols — used after inflammation is under control and exposure is removed. People report better energy, clearer thinking, easier breathing, and steadier gut function. It also calms immune overreaction and improves circulation.
Mechanism
Acts on VPAC1/VPAC2 receptors to dilate blood vessels, damp inflammatory signalling, support the gut mucosal barrier, and regulate hypothalamic hormone rhythms.
Storage — lyophilisedwhat's this?
Refrigerate the nasal spray.
Storage — reconstitutedwhat's this?
Keep refrigerated and use within the pharmacy-stated window.
Reconstitution noteswhat's this?
Supplied as a compounded nasal spray, typically 50 mcg per spray, up to four times a day. Standard practice is to correct inflammatory markers, clear MARCoNS, and remove mold exposure before starting.
Stacks well with
- KPVBoth calm inflammatory signalling, especially in the gut.
- Thymosin Alpha-1Immune regulation alongside vascular and mucosal support.
Popular combinations reported in the community and research literature — not a recommendation. Adding peptides multiplies side-effect risk; check with a clinician.
Commonly reported side effects
- Flushing
- Low blood pressure
- Loose stools
- Nasal irritation
Contraindications noted
- Low blood pressure
- Active untreated infection
- Ongoing mold exposure
Research notes
Best known from the Shoemaker CIRS protocol, where sequencing matters more than dose.
Track this properly
Work out syringe units with the calculator, or set up a full schedule in about a minute.
Reference information only, not medical advice. See our medical disclaimer.