KPV

What it does

A three-amino-acid fragment of the alpha-MSH hormone. Its whole job is turning down inflammation, and unlike steroids it does this without suppressing the immune system broadly. What people look into it for: • Gut inflammation — IBD, colitis and general gut irritation • Skin conditions such as eczema, acne, psoriasis and slow-healing wounds • General inflammation without immune suppression • Some antimicrobial activity It can be taken orally for gut issues, applied topically for skin, or injected.

Mechanism

Inhibits NF-kB signalling and pro-inflammatory cytokine release.

Storage — lyophilised

Refrigerate 2-8C, protect from light.

Storage — reconstituted

Refrigerate 2-8C, use within ~28 days.

Reconstitution notes

Add 2 ml bacteriostatic water to a 5 mg vial for 25 mcg per unit; often taken orally for gut targets.

Commonly stacked with

• BPC-157

Commonly reported side effects

• Injection-site irritation
• Mild fatigue

Contraindications noted

• Pregnancy or breastfeeding

Research notes

Preclinical colitis and dermatitis models dominate the evidence.