PT-141
Also known as Bremelanotide, Vyleesi
Melanocortin agonist for sexual desire and arousal.
- Category
- hormone
- Route
- subq
- Documented dose
- 500–1750 mcg
- Typical frequency
- As needed, max ~2 per week
- Half-life
- ~2.7 hours
- Common vial sizes
- 10 mg
- Regulatory status
- FDA-approved as Vyleesi for a specific indication.
What it does
Also called bremelanotide and approved as Vyleesi. Unlike Viagra-type drugs, which work on blood flow, this one works in the brain on the pathways that create desire itself. What people look into it for: • Low sexual desire in both women and men • Arousal problems that have not responded to blood-flow medications • Situations where the issue is wanting rather than physical ability It is used occasionally, roughly 45 minutes to a few hours before activity, not daily. Nausea and temporary flushing are common.
Mechanism
MC3R/MC4R agonist acting centrally on arousal pathways.
Storage — lyophilised
Refrigerate 2-8C, protect from light.
Storage — reconstituted
Refrigerate 2-8C, use within ~28 days.
Reconstitution notes
Add 2 ml bacteriostatic water to a 10 mg vial for 50 mcg per unit.
Commonly reported side effects
- Nausea
- Flushing
- Headache
- Transient blood pressure rise
- Skin darkening
Contraindications noted
- Uncontrolled hypertension
- Cardiovascular disease
- Pregnancy
Research notes
Nausea is dose-dependent and common; start low.
Track this properly
Work out syringe units with the free calculator, or set up a full schedule in about a minute.
Reference information only, not medical advice. See our medical disclaimer.