Kisspeptin-10

What it does

A signalling peptide that sits at the very top of the reproductive hormone chain. It tells the brain to release LH and FSH, which in turn tell the testes or ovaries to make testosterone or oestrogen. What people look into it for: • Supporting the body's own testosterone production rather than replacing it • Fertility testing and treatment research • Libido and sexual motivation — it also acts on emotional and reward areas of the brain • Restarting hormone signalling after suppression Effects are short-lived because it clears from the body quickly.

Mechanism

Stimulates GnRH neurons via KISS1R, increasing LH and FSH.

Storage — lyophilised

Refrigerate 2-8C, protect from light.

Storage — reconstituted

Refrigerate 2-8C, use within ~28 days.

Reconstitution notes

Add 2 ml bacteriostatic water to a 5 mg vial for 25 mcg per unit.

Commonly stacked with

• PT-141

Commonly reported side effects

• Flushing
• Headache
• Nausea

Contraindications noted

• Hormone-sensitive cancers
• Pregnancy

Research notes

Mostly used as a research probe of the HPG axis.